Loss of HLA haplotype in lung cancer cell lines: implications for immunosurveillance of altered HLA class I/II phenotypes in lung cancer.

Obstructive sleep apnea and perioperative complications.

We read with great interest the article in CHEST (July 2002) by Masakazu et al,1 who observed a haplotype loss of class I human leukocyte antigens (HLAs) in several newly established lung cancer cell lines and identified it as a mechanism of tumor escape from the immunosurveillance system of the host. However, as for the HLA genes of lung cancer cell lines passing for many generations, such as ...

Human leukocyte antigen-ABDR genes in pulmonary adenocarcinoma cell lines.

We read with great interest the article in CHEST (July 2002) by Masakazu et al,1 who observed a haplotype loss of class I human leukocyte antigens (HLAs) in several newly established lung cancer cell lines and identified it as a mechanism of tumor escape from the immunosurveillance system of the host. However, as for the HLA genes of lung cancer cell lines passing for many generations, such as ...

Multiple Genetic Alterations Cause Frequent and Heterogeneous Human Histocompatibility Leukocyte Antigen Class I Loss in Cervical Cancer

The nature and frequency of human histocompatibility leukocyte antigen (HLA) class I loss mechanisms in primary cancers are largely unknown. We used flow cytometry and molecular analyses to concurrently assess allele-specific HLA phenotypes and genotypes in subpopulations from 30 freshly isolated cervical tumor cell suspensions.Tumor-associated HLA class I alterations were present in 90% of the...

HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape

Immune-checkpoint inhibitors show encouraging results in cancer treatment, but the clinical benefit is limited exclusively to a subset of patients. We analyzed the density and composition of tumor T-cell infiltration in non-small-cell lung carcinoma (NSCLC) in relation to PD-L1 and HLA class I (HLA-I) expression. We found that positive HLA-I expression, independently on PD-L1 status, is the key...

HLA Class I Allele Frequencies in Southern Iranian Women with Breast Cancer